Version 5.4
Bos taurus Protein: ARHGAP15
Summary
InnateDB Protein IDBP-694548.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGAP15
Protein Name Rho GTPase-activating protein 15
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000053462
InnateDB Gene IDBG-642128 (ARHGAP15)
Protein Structure
UniProt Annotation
Function GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0030675 Rac GTPase activator activity
Biological Process
GO:0007165 signal transduction
GO:0008360 regulation of cell shape
GO:0032855 positive regulation of Rac GTPase activity
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000198 Rho GTPase-activating protein domain
IPR001849 Pleckstrin homology domain
IPR008936 Rho GTPase activation protein
PFAM PF00620
PF00169
PRINTS
PIRSF
SMART SM00324
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A4IF90
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 616246
UniGene Bt.92052
RefSeq NP_001098473
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC134460
GenPept AAI34461

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca