Version 5.4
Bos taurus Protein: TTLL1
Summary
InnateDB Protein IDBP-694557.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TTLL1
Protein Name Probable tubulin polyglutamylase TTLL1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000015956
InnateDB Gene IDBG-642132 (TTLL1)
Protein Structure
UniProt Annotation
Function Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016874 ligase activity
Biological Process
GO:0003351 epithelial cilium movement
GO:0006464 cellular protein modification process
GO:0018095 protein polyglutamylation
GO:0035082 axoneme assembly
GO:0044782 cilium organization
GO:0060271 cilium morphogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
Protein Structure and Domains
PDB ID
InterPro IPR004344 Tubulin-tyrosine ligase/Tubulin polyglutamylase
PFAM PF03133
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0VC71
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 539530
UniGene Bt.14078
RefSeq NP_001069639
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120322
GenPept AAI20323

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca