Version 5.4
Bos taurus Protein: HNMT
Summary
InnateDB Protein IDBP-694597.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HNMT
Protein Name Histamine N-methyltransferase
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000019196
InnateDB Gene IDBG-642173 (HNMT)
Protein Structure
UniProt Annotation
Function Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008168 methyltransferase activity
GO:0008170 N-methyltransferase activity
GO:0016740 transferase activity
GO:0046539 histamine N-methyltransferase activity
Biological Process
GO:0032259 methylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR013217 Methyltransferase type 12
IPR016673 Histamine N-methyltransferase
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM PF08242
PRINTS
PIRSF PIRSF016616
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q58DV7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 613413
UniGene Bt.65743
RefSeq NP_001030511
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC114060 BT021490
GenPept AAI14061 AAX46337

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca