Version 5.4
Bos taurus Protein: SPATA18
Summary
InnateDB Protein IDBP-694664.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPATA18
Protein Name Mitochondria-eating protein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000024097
InnateDB Gene IDBG-642222 (SPATA18)
Protein Structure
UniProt Annotation
Function Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}. Note=Localizes to the cytoplasm under normal conditions. Relocalizes to mitochondrion outer membrane following cellular stress (By similarity). Colocalizes with BNIP3 and BNIP3L at the mitochondrion outer membrane (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006974 cellular response to DNA damage stimulus
GO:0033554 cellular response to stress
GO:0035694 mitochondrial protein catabolic process
GO:0035695 mitochondrion degradation by induced vacuole formation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt E1BLK7
PhosphoSite PhosphoSite-
TrEMBL G5E5K9
UniProt Splice Variant
Entrez Gene 615729
UniGene Bt.51755
RefSeq XP_002688316
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AAFC03100124 AAFC03100125 AAFC03100129 AAFC03100133 AAFC03104636 AAFC03104637 AAFC03122887 DAAA02017661 DAAA02017662 DAAA02017663
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca