InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SLC17A6

Summary

InnateDB Protein

IDBP-694686.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC17A6

Protein Name

Vesicular glutamate transporter 2

Synonyms

VGluT2;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000007935

InnateDB Gene

IDBG-642246 (SLC17A6)

Protein Structure

UniProt Annotation

Function

Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, synapse, synaptosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005313	L-glutamate transmembrane transporter activity
GO:0015293	symporter activity

Biological Process

GO:0001504	neurotransmitter uptake
GO:0006810	transport
GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0006836	neurotransmitter transport
GO:0015813	L-glutamate transport
GO:0055085	transmembrane transport

Cellular Component

GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030672	synaptic vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0043005	neuron projection
GO:0045202	synapse

Protein Structure and Domains

PDB ID

InterPro

IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A6QLI1

PhosphoSite