InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: UPK3A

Summary

InnateDB Protein

IDBP-694707.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UPK3A

Protein Name

Uroplakin-3a

Synonyms

UP3a; UPIII; Upk3;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000013081

InnateDB Gene

IDBG-642267 (UPK3A)

Protein Structure

UniProt Annotation

Function

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:12475947}; Single-pass type I membrane protein {ECO:0000269PubMed:12475947}. Note=Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).

Disease Associations

Tissue Specificity

Bladder epithelium.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000902	cell morphogenesis
GO:0001822	kidney development
GO:0006833	water transport
GO:0015840	urea transport
GO:0030855	epithelial cell differentiation
GO:0055075	potassium ion homeostasis
GO:0055078	sodium ion homeostasis
GO:0060157	urinary bladder development

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P38574

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

100336102

UniGene

Bt.60952

RefSeq

NP_777134

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

L19542

GenPept

AAC37309