Version 5.4
Bos taurus Protein: DCXR
Summary
InnateDB Protein IDBP-694716.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCXR
Protein Name L-xylulose reductase
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000048055
InnateDB Gene IDBG-642275 (DCXR)
Protein Structure
UniProt Annotation
Function Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Probably recruited to membranes via an interaction with phosphatidylinositol. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0050038 L-xylulose reductase (NADP+) activity
GO:0050662 coenzyme binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005997 xylulose metabolic process
GO:0006006 glucose metabolic process
GO:0006739 NADP metabolic process
GO:0008152 metabolic process
GO:0042732 D-xylose metabolic process
GO:0051289 protein homotetramerization
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005881 cytoplasmic microtubule
GO:0005902 microvillus
GO:0005903 brush border
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
IPR006151 Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
IPR013968 Polyketide synthase, KR
PFAM PF01370
PF00106
PF01488
PF08659
PRINTS PR00080
PR00081
PR01397
PIRSF PIRSF000126
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q1JP75
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 526937
UniGene Bt.88379
RefSeq NP_001069359
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BT025479
GenPept ABF57435

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca