Version 5.4
Bos taurus Protein: PDGFRA
Summary
InnateDB Protein IDBP-694766.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDGFRA
Protein Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000009441
InnateDB Gene IDBG-642308 (PDGFRA)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005018 platelet-derived growth factor alpha-receptor activity
GO:0005021 vascular endothelial growth factor-activated receptor activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0038085 vascular endothelial growth factor binding
GO:0042803 protein homodimerization activity
GO:0048407 platelet-derived growth factor binding
Biological Process
GO:0001553 luteinization
GO:0001701 in utero embryonic development
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008210 estrogen metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0008585 female gonad development
GO:0009653 anatomical structure morphogenesis
GO:0009887 organ morphogenesis
GO:0010544 negative regulation of platelet activation
GO:0010863 positive regulation of phospholipase C activity
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030198 extracellular matrix organization
GO:0030324 lung development
GO:0030325 adrenal gland development
GO:0030335 positive regulation of cell migration
GO:0030539 male genitalia development
GO:0033327 Leydig cell differentiation
GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway
GO:0038091 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0042060 wound healing
GO:0042475 odontogenesis of dentin-containing tooth
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045740 positive regulation of DNA replication
GO:0046777 protein autophosphorylation
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048146 positive regulation of fibroblast proliferation
GO:0048557 embryonic digestive tract morphogenesis
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0050920 regulation of chemotaxis
GO:0055003 cardiac myofibril assembly
GO:0060021 palate development
GO:0060325 face morphogenesis
GO:0060326 cell chemotaxis
GO:0061298 retina vasculature development in camera-type eye
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070527 platelet aggregation
GO:0071230 cellular response to amino acid stimulus
GO:0072277 metanephric glomerular capillary formation
GO:2000739 regulation of mesenchymal stem cell differentiation
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0005902 microvillus
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031226 intrinsic component of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR016243 Tyrosine-protein kinase, CSF-1/PDGF receptor
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PF07679
PRINTS PR00109
PIRSF PIRSF000615
PIRSF500947
SMART SM00220
SM00408
SM00409
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q6RXL2
UniProt Splice Variant
Entrez Gene 282301
UniGene Bt.96650
RefSeq NP_001179274
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY486456 DAAA02017695
GenPept AAR27833

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca