InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SAMHD1

Summary

InnateDB Protein

IDBP-694956.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SAMHD1

Protein Name

SAM domain and HD domain-containing protein 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000041236

InnateDB Gene

IDBG-642493 (SAMHD1)

Protein Structure

UniProt Annotation

Function

Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003824	catalytic activity
GO:0008081	phosphoric diester hydrolase activity
GO:0008270	zinc ion binding
GO:0008832	dGTPase activity
GO:0016787	hydrolase activity
GO:0032567	dGTP binding
GO:0046872	metal ion binding

Biological Process

GO:0002376	immune system process
GO:0006203	dGTP catabolic process
GO:0008152	metabolic process
GO:0045087	innate immune response
GO:0045088	regulation of innate immune response
GO:0046061	dATP catabolic process
GO:0051289	protein homotetramerization
GO:0051607	defense response to virus