InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BTN2A1

Summary

InnateDB Protein

IDBP-69498.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BTN2A1

Protein Name

butyrophilin, subfamily 2, member A1

Synonyms

BK14H9.1; BT2.1; BTF1; BTN2.1; DJ3E1.1;

Species

Homo sapiens

Ensembl Protein

ENSP00000312158

InnateDB Gene

IDBG-69496 (BTN2A1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in brain, bone marrow, small intestine, muscle, spleen and pancreas. Moderate expression was seen in lung, liver and kidney. {ECO:0000269PubMed:9149941}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0006629

lipid metabolic process

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001870 B30.2/SPRY domain
IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR003877 SPRY domain
IPR003879 Butyrophylin-like
IPR006574 SPRY-associated
IPR007110 Immunoglobulin-like domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR013106 Immunoglobulin V-set domain
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF00622
PF13765
PF07686
PF08205

PRINTS

PR01407

PIRSF

SMART

SM00406
SM00409
SM00449
SM00589

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt