Version 5.4
Bos taurus Protein: PPP1R16B
Summary
InnateDB Protein IDBP-695121.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP1R16B
Protein Name Protein phosphatase 1 regulatory inhibitor subunit 16B
Synonyms TIMAP;
Species Bos taurus
Ensembl Protein ENSBTAP00000000858
InnateDB Gene IDBG-642646 (PPP1R16B)
Protein Structure
UniProt Annotation
Function Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}. Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Nucleus {ECO:0000250}. Note=Colocalizes with RPSA/LAMR1 in the cell membrane. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0051489 regulation of filopodium assembly
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR002110 Ankyrin repeat
IPR017417 Protein phosphatase 1, regulatory subunit 16A/B, eukaryote
IPR020683 Ankyrin repeat-containing domain
PFAM PF00023
PF13606
PF11929
PF12796
PRINTS PR01415
PIRSF PIRSF038159
SMART SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q95N27
PhosphoSite PhosphoSite-Q95N27
TrEMBL
UniProt Splice Variant
Entrez Gene 282091
UniGene Bt.8543
RefSeq NP_777249
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF362909
GenPept AAK52795

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca