InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PLCG1

Summary

InnateDB Protein

IDBP-695175.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLCG1

Protein Name

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000023383

InnateDB Gene

IDBG-642685 (PLCG1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 156 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	156 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004871	signal transducer activity
GO:0005168	neurotrophin TRKA receptor binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity
GO:0016787	hydrolase activity
GO:0019901	protein kinase binding
GO:0030971	receptor tyrosine kinase binding
GO:0035254	glutamate receptor binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0009395	phospholipid catabolic process
GO:0010634	positive regulation of epithelial cell migration
GO:0016042	lipid catabolic process
GO:0016477	cell migration
GO:0019722	calcium-mediated signaling
GO:0035556	intracellular signal transduction
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0045766	positive regulation of angiogenesis
GO:0050852	T cell receptor signaling pathway
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0071364	cellular response to epidermal growth factor stimulus

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0008180	COP9 signalosome
GO:0030027	lamellipodium
GO:0042995	cell projection

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR000980 SH2 domain
IPR001192 Phosphoinositide phospholipase C family
IPR001452 SH3 domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR001849 Pleckstrin homology domain
IPR002048 EF-hand domain
IPR011511 Variant SH3 domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR016279 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

PFAM

PF00168
PF00388
PF00017
PF14633
PF00018
PF14604
PF00387
PF00169
PF00036
PF13202
PF13405
PF07653
PF09279

PRINTS

PR00360
PR00401
PR00390
PR00452

PIRSF

PIRSF000952

SMART

SM00239
SM00148
SM00252
SM00326
SM00149
SM00233
SM00054

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

F1MYF9

UniProt Splice Variant

Entrez Gene

281987

UniGene

Bt.307

RefSeq

NP_776850

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02036645

GenPept