InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FOXJ1

Summary

InnateDB Protein

IDBP-69531.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOXJ1

Protein Name

forkhead box J1

Synonyms

FKHL13; HFH-4; HFH4;

Species

Homo sapiens

Ensembl Protein

ENSP00000323880

InnateDB Gene

IDBG-69529 (FOXJ1)

Protein Structure

UniProt Annotation

Function

May play an important role in cell fate determination during lung development and in spermatogenesis. {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Allergic rhinitis (ALRH) [MIM:607154]: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure. {ECO:0000269PubMed:16518568}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Tissue Specificity

Testis, oviduct, lung and brain cortex.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002508	central tolerance induction
GO:0002635	negative regulation of germinal center formation
GO:0002897	positive regulation of central B cell tolerance induction
GO:0002924	negative regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006959	humoral immune response
GO:0007283	spermatogenesis
GO:0007389	pattern specification process
GO:0007420	brain development
GO:0030036	actin cytoskeleton organization
GO:0030856	regulation of epithelial cell differentiation
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032862	activation of Rho GTPase activity
GO:0033085	negative regulation of T cell differentiation in thymus
GO:0035089	establishment of apical/basal cell polarity
GO:0035502	metanephric part of ureteric bud development
GO:0042130	negative regulation of T cell proliferation
GO:0042384	cilium assembly
GO:0045409	negative regulation of interleukin-6 biosynthetic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050869	negative regulation of B cell activation
GO:0050900	leukocyte migration
GO:0060271	cilium morphogenesis
GO:0060428	lung epithelium development
GO:0060429	epithelium development
GO:0060972	left/right pattern formation
GO:0072016	glomerular parietal epithelial cell development
GO:1901248	positive regulation of lung ciliated cell differentiation