Version 5.4
Bos taurus Protein: SHANK3
Summary
InnateDB Protein IDBP-695335.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SHANK3
Protein Name SH3 and multiple ankyrin repeat domains 3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000040212
InnateDB Gene IDBG-642826 (SHANK3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0035255 ionotropic glutamate receptor binding
GO:0097110 scaffold protein binding
Biological Process
GO:0000165 MAPK cascade
GO:0001838 embryonic epithelial tube formation
GO:0007416 synapse assembly
GO:0007612 learning
GO:0007613 memory
GO:0021773 striatal medium spiny neuron differentiation
GO:0032232 negative regulation of actin filament bundle assembly
GO:0035176 social behavior
GO:0035641 locomotory exploration behavior
GO:0045794 negative regulation of cell volume
GO:0048170 positive regulation of long-term neuronal synaptic plasticity
GO:0048854 brain morphogenesis
GO:0050885 neuromuscular process controlling balance
GO:0051835 positive regulation of synapse structural plasticity
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060997 dendritic spine morphogenesis
GO:0060999 positive regulation of dendritic spine development
GO:0061001 regulation of dendritic spine morphogenesis
GO:0071625 vocalization behavior
GO:0097107 postsynaptic density assembly
GO:0097113 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering
GO:0097114 N-methyl-D-aspartate receptor clustering
GO:0097117 guanylate kinase-associated protein clustering
GO:1900271 regulation of long-term synaptic potentiation
GO:1900451 positive regulation of glutamate receptor signaling pathway
GO:1900452 regulation of long term synaptic depression
GO:2000463 positive regulation of excitatory postsynaptic membrane potential
GO:2000821 regulation of grooming behavior
GO:2000822 regulation of behavioral fear response
GO:2000969 positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Cellular Component
GO:0005886 plasma membrane
GO:0043005 neuron projection
GO:0044309 neuron spine
Protein Structure and Domains
PDB ID
InterPro IPR001452 SH3 domain
IPR001478 PDZ domain
IPR001660 Sterile alpha motif domain
IPR002110 Ankyrin repeat
IPR011510 Sterile alpha motif, type 2
IPR011511 Variant SH3 domain
IPR013761 Sterile alpha motif/pointed domain
IPR020683 Ankyrin repeat-containing domain
IPR021129 Sterile alpha motif, type 1
PFAM PF00018
PF14604
PF00595
PF13180
PF00023
PF13606
PF07647
PF07653
PF11929
PF12796
PF00536
PRINTS PR00452
PR01415
PIRSF
SMART SM00326
SM00228
SM00454
SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL G3X7P4
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02015062 DAAA02015063 DAAA02015064 DAAA02015065 DAAA02015066
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca