InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: GADD45GIP1

Summary

InnateDB Protein

IDBP-695382.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GADD45GIP1

Protein Name

Growth arrest and DNA damage-inducible proteins-interacting protein 1

Synonyms

MRP-L59;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000020114

InnateDB Gene

IDBG-642884 (GADD45GIP1)

Protein Structure

UniProt Annotation

Function

Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007049

cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR018472 Growth arrest/ DNA-damage-inducible protein-interacting protein 1

PFAM

PF10147

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A1A4P4

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

504718

UniGene

Bt.85770

RefSeq

NP_001073693

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC126785

GenPept

AAI26786