Version 5.4
Bos taurus Protein: RNASEH2A
Summary
InnateDB Protein IDBP-695441.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNASEH2A
Protein Name Ribonuclease H2 subunit A
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000012731
InnateDB Gene IDBG-642932 (RNASEH2A)
Protein Structure
UniProt Annotation
Function Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. {ECO:0000269PubMed:9789007}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006298 mismatch repair
GO:0006401 RNA catabolic process
GO:0016070 RNA metabolic process
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0005634 nucleus
GO:0032299 ribonuclease H2 complex
Protein Structure and Domains
PDB ID
InterPro IPR004649 Ribonuclease H2, subunit A
IPR012337 Ribonuclease H-like domain
IPR024567 Ribonuclease HII/HIII domain
PFAM PF01351
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2TBT5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 512830
UniGene Bt.44367
RefSeq NP_001033623
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC109682
GenPept AAI09683

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca