InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: DHPS

Summary

InnateDB Protein

IDBP-695522.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DHPS

Protein Name

Deoxyhypusine synthase

Synonyms

DYS;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000008200

InnateDB Gene

IDBG-643008 (DHPS)

Protein Structure

UniProt Annotation

Function

Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016740	transferase activity
GO:0034038	deoxyhypusine synthase activity

Biological Process

GO:0008612	peptidyl-lysine modification to peptidyl-hypusine
GO:0042102	positive regulation of T cell proliferation
GO:0042593	glucose homeostasis
GO:0050983	deoxyhypusine biosynthetic process from spermidine

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR002773 Deoxyhypusine synthase
IPR029035 DHS-like NAD/FAD-binding domain

PFAM

PF01916

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6EWQ6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

444988

UniGene

Bt.3902

RefSeq

NP_001003657

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AJ577610 BC105230

GenPept

AAI05231 CAE12195