InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CXCL6

Summary

InnateDB Protein

IDBP-695529.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXCL6

Protein Name

C-X-C motif chemokine 6

Synonyms

CXCL5; GCP-2; GCP2; SCYB6;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000012939

InnateDB Gene

IDBG-643013 (CXCL6)

Protein Structure

UniProt Annotation

Function

Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram- negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7) (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0008009	chemokine activity
GO:0008201	heparin binding

Biological Process

GO:0001776	leukocyte homeostasis
GO:0006935	chemotaxis
GO:0006955	immune response
GO:0032496	response to lipopolysaccharide
GO:0032642	regulation of chemokine production
GO:0042742	defense response to bacterium
GO:0060326	cell chemotaxis
GO:0070951	regulation of neutrophil mediated killing of gram-negative bacterium

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

InterPro

IPR001089 CXC chemokine
IPR001811 Chemokine interleukin-8-like domain

PFAM

PF00048

PRINTS

PR00437

PIRSF

SMART

SM00199

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P80221

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

281735

UniGene

Bt.7165

RefSeq

NP_776725

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF149249 BC142108

GenPept

AAG35212 AAI42109