InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SRSF2

Summary

InnateDB Protein

IDBP-695532.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRSF2

Protein Name

Serine/arginine-rich splicing factor 2

Synonyms

SFRS2;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000024299

InnateDB Gene

IDBG-643017 (SRSF2)

Protein Structure

UniProt Annotation

Function

Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre- mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Nucleus speckle {ECO:0000250}. Note=Phosphorylation by SRPK2 provokes its redistribution from the nuclear specke to nucleoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.

Predicted by orthology
Total	74 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding

Biological Process

GO:0006397	mRNA processing
GO:0008380	RNA splicing

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0016607	nuclear speck

Protein Structure and Domains

PDB ID

InterPro

IPR000504 RNA recognition motif domain
IPR003954 RNA recognition motif domain, eukaryote

PFAM

PF00076

PRINTS

PIRSF

SMART

SM00360
SM00361

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3MHR5

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

508312

UniGene

Bt.2466

RefSeq

NP_001029490

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC105138

GenPept

AAI05139