Version 5.4
Bos taurus Protein: CXCL10
Summary
InnateDB Protein IDBP-695637.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CXCL10
Protein Name C-X-C motif chemokine 10
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000039324
InnateDB Gene IDBG-643109 (CXCL10)
Protein Structure
UniProt Annotation
Function Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0008009 chemokine activity
GO:0008201 heparin binding
GO:0048248 CXCR3 chemokine receptor binding
Biological Process
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0010818 T cell chemotaxis
GO:0030335 positive regulation of cell migration
GO:0030816 positive regulation of cAMP metabolic process
GO:0042127 regulation of cell proliferation
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051607 defense response to virus
GO:0060326 cell chemotaxis
GO:0070098 chemokine-mediated signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:2000406 positive regulation of T cell migration
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009897 external side of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR001089 CXC chemokine
IPR001811 Chemokine interleukin-8-like domain
PFAM PF00048
PRINTS PR00437
PIRSF
SMART SM00199
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2KIQ8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 615107
UniGene Bt.60947
RefSeq NP_001040016
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC112547 EU276062
GenPept AAI12548 ABX72060

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca