Version 5.4
Bos taurus Protein: ENOPH1
Summary
InnateDB Protein IDBP-695730.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ENOPH1
Protein Name Enolase-phosphatase E1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000019702
InnateDB Gene IDBG-643190 (ENOPH1)
Protein Structure
UniProt Annotation
Function Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene). {ECO:0000255HAMAP-Rule:MF_03117}.
Subcellular Localization Cytoplasm {ECO:0000255HAMAP-Rule:MF_03117}. Nucleus {ECO:0000255HAMAP-Rule:MF_03117}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0016787 hydrolase activity
GO:0043874 acireductone synthase activity
GO:0046872 metal ion binding
Biological Process
GO:0008152 metabolic process
GO:0008652 cellular amino acid biosynthetic process
GO:0009086 methionine biosynthetic process
GO:0016311 dephosphorylation
GO:0019509 L-methionine biosynthetic process from methylthioadenosine
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR006439 HAD hydrolase, subfamily IA
IPR023214 HAD-like domain
IPR023943 Enolase-phosphatase E1
PFAM PF00702
PF08282
PF13419
PRINTS PR00413
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0VD27
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 525563
UniGene Bt.3244
RefSeq NP_001069343
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC119871
GenPept AAI19872

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca