Version 5.4
Bos taurus Protein: FLIP
Summary
InnateDB Protein IDBP-695744.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FLIP
Protein Name CASP8 and FADD-like apoptosis regulator
Synonyms FLIP;
Species Bos taurus
Ensembl Protein ENSBTAP00000014607
InnateDB Gene IDBG-643202 (FLIP)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.
Predicted by orthology
Total 54 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0004197 cysteine-type endopeptidase activity
GO:0005515 protein binding
GO:0008047 enzyme activator activity
GO:0008234 cysteine-type peptidase activity
GO:0035877 death effector domain binding
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0042981 regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0060544 regulation of necroptotic process
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0031264 death-inducing signaling complex
GO:0097342 ripoptosome
Protein Structure and Domains
PDB ID
InterPro IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR001875 Death effector domain
IPR011029 Death-like domain
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core
PFAM PF01335
PF00656
PRINTS PR00376
PIRSF
SMART SM00031
SM00115
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q5FX62
UniProt Splice Variant
Entrez Gene 497199
UniGene Bt.111455
RefSeq NP_001012281
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY882619 DAAA02005587
GenPept AAW65490

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca