Version 5.4
| Bos taurus Protein: RNF114 | |||||||||||
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| Summary | |||||||||||
| InnateDB Protein | IDBP-695747.2 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | RNF114 | ||||||||||
| Protein Name | RING finger protein 114 | ||||||||||
| Synonyms | Znf313; | ||||||||||
| Species | Bos taurus | ||||||||||
| Ensembl Protein | ENSBTAP00000038956 | ||||||||||
| InnateDB Gene | IDBG-643206 (RNF114) | ||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||
| Function | E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle's G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis (By similarity). {ECO:0000250}. | ||||||||||
| Subcellular Localization | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. | ||||||||||
| Disease Associations | |||||||||||
| Tissue Specificity | |||||||||||
| Comments | |||||||||||
| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||
| PDB ID | |||||||||||
| InterPro |
IPR001841
Zinc finger, RING-type IPR008598 Drought induced 19 protein-like, zinc-binding domain IPR018957 Zinc finger, C3HC4 RING-type |
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| PFAM |
PF13639
PF14634 PF05605 PF00097 |
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| PRINTS | |||||||||||
| PIRSF | |||||||||||
| SMART |
SM00184
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| TIGRFAMs | |||||||||||
| Post-translational Modifications | |||||||||||
| Modification | |||||||||||
| Cross-References | |||||||||||
| SwissProt | Q4U5R4 | ||||||||||
| PhosphoSite | PhosphoSite- | ||||||||||
| TrEMBL | |||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 513479 | ||||||||||
| UniGene | Bt.68968 | ||||||||||
| RefSeq | NP_001019702 | ||||||||||
| HUGO | |||||||||||
| OMIM | |||||||||||
| CCDS | |||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | BC102412 BT030581 DQ010409 | ||||||||||
| GenPept | AAI02413 AAY33866 ABQ13021 | ||||||||||