Homo sapiens Protein: BTN1A1
Summary
InnateDB Protein IDBP-69577.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BTN1A1
Protein Name butyrophilin, subfamily 1, member A1
Synonyms BT; BTN; BTN1;
Species Homo sapiens
Ensembl Protein ENSP00000244513
InnateDB Gene IDBG-69573 (BTN1A1)
Protein Structure
UniProt Annotation
Function May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity). {ECO:0000250}.
Subcellular Localization Membrane; Single-pass type I membrane protein. Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005615 extracellular space
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR001870 B30.2/SPRY domain
IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR003877 SPRY domain
IPR003879 Butyrophylin-like
IPR006574 SPRY-associated
IPR007110 Immunoglobulin-like domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR013106 Immunoglobulin V-set domain
IPR013162 CD80-like, immunoglobulin C2-set
PFAM PF00622
PF13765
PF07686
PF08205
PRINTS PR01407
PIRSF
SMART SM00406
SM00409
SM00449
SM00589
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13410
PhosphoSite PhosphoSite-Q13410
TrEMBL
UniProt Splice Variant
Entrez Gene 696
UniGene Hs.153058
RefSeq NP_001723
HUGO HGNC:1135
OMIM 601610
CCDS CCDS4614
HPRD 03365
IMGT
EMBL AL121936 BC096312 BC096313 CH471087 U39576
GenPept AAC50489 AAH96312 AAH96313 CAC16802 EAW55585