Version 5.4
Bos taurus Protein: NUP85
Summary
InnateDB Protein IDBP-695872.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUP85
Protein Name Nuclear pore complex protein Nup85
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000034574
InnateDB Gene IDBG-643313 (NUP85)
Protein Structure
UniProt Annotation
Function Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP98/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2- activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl- inositol 3-kinase-Rac-lammellipodium protrusion cascade (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nuclear pore complex {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus membrane {ECO:0000250}. Note=During mitosis, localizes to the kinetochores and spindle poles. Upon CCl2 stimulation translocates from the cytoplasm to the membrane and colocalizes with CCR2 at the front of migrating cells (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0006935 chemotaxis
GO:0015031 protein transport
GO:0030032 lamellipodium assembly
GO:0048246 macrophage chemotaxis
GO:0051028 mRNA transport
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0031080 nuclear pore outer ring
GO:0031965 nuclear membrane
Protein Structure and Domains
PDB ID
InterPro IPR011502 Nucleoporin Nup85-like
PFAM PF07575
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3ZC98
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 510540
UniGene Bt.8317
RefSeq NP_001029559
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102703 BT030744
GenPept AAI02704 ABS45060

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca