Version 5.4
Bos taurus Protein: WDR12
Summary
InnateDB Protein IDBP-695879.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WDR12
Protein Name Ribosome biogenesis protein WDR12
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000020499
InnateDB Gene IDBG-643324 (WDR12)
Protein Structure
UniProt Annotation
Function Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255HAMAP-Rule:MF_03029}.
Subcellular Localization Nucleus, nucleolus {ECO:0000255HAMAP- Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255HAMAP- Rule:MF_03029}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0043021 ribonucleoprotein complex binding
Biological Process
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0007219 Notch signaling pathway
GO:0008283 cell proliferation
GO:0042254 ribosome biogenesis
GO:0042273 ribosomal large subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0030687 preribosome, large subunit precursor
GO:0070545 PeBoW complex
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR012972 NLE
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
PFAM PF00400
PF08154
PRINTS PR00320
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0VC24
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 528209
UniGene Bt.42368
RefSeq NP_001069375
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120386 BC142121 BT029892
GenPept AAI20387 AAI42122 ABM06142

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca