InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHST12

Summary

InnateDB Protein

IDBP-6959.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHST12

Protein Name

carbohydrate (chondroitin 4) sulfotransferase 12

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000258711

InnateDB Gene

IDBG-6957 (CHST12)

Protein Structure

UniProt Annotation

Function

Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. Expressed a high level in spinal chord, heart, spleen, thyroid, pituitary gland, adrenal gland, peripheral blood leukocytes, thymus, lung, small intestine, fetal kidney, fetal spleen and fetal lung. {ECO:0000269PubMed:10781601}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008146	sulfotransferase activity
GO:0047756	chondroitin 4-sulfotransferase activity
GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0016051	carbohydrate biosynthetic process
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0030208	dermatan sulfate biosynthetic process
GO:0044281	small molecule metabolic process