InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APBA1

Summary

InnateDB Protein

IDBP-69590.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APBA1

Protein Name

amyloid beta (A4) precursor protein-binding, family A, member 1

Synonyms

D9S411E; LIN10; MINT1; X11; X11A; X11ALPHA;

Species

Homo sapiens

Ensembl Protein

ENSP00000265381

InnateDB Gene

IDBG-69588 (APBA1)

Protein Structure

UniProt Annotation

Function

Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta- amyloid precursor protein (APP) and hence formation of beta-APP.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:20531236}. Cytoplasm, perinuclear region {ECO:0000269PubMed:20531236}. Nucleus {ECO:0000269PubMed:20531236}. Note=Only about 5% of the protein is located in the nucleus.Isoform 2: Golgi apparatus {ECO:0000269PubMed:23737971}.

Disease Associations

Tissue Specificity

Brain and spinal cord. Isoform 2 is expressed in testis and brain, but not detected in lung, liver or spleen. {ECO:0000269PubMed:23737971}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0030165	PDZ domain binding
GO:0032403	protein complex binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006461	protein complex assembly
GO:0006886	intracellular protein transport
GO:0007155	cell adhesion
GO:0007268	synaptic transmission
GO:0007399	nervous system development
GO:0007626	locomotory behavior
GO:0008088	axon cargo transport
GO:0010468	regulation of gene expression
GO:0014047	glutamate secretion
GO:0014051	gamma-aminobutyric acid secretion
GO:0035264	multicellular organism growth

Cellular Component

GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm