Version 5.4
Bos taurus Protein: WFS1
Summary
InnateDB Protein IDBP-695917.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WFS1
Protein Name Wolfram syndrome 1 (wolframin)
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000056322
InnateDB Gene IDBG-643358 (WFS1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0031625 ubiquitin protein ligase binding
GO:0033613 activating transcription factor binding
GO:0051117 ATPase binding
Biological Process
GO:0001822 kidney development
GO:0003091 renal water homeostasis
GO:0007601 visual perception
GO:0007605 sensory perception of sound
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031398 positive regulation of protein ubiquitination
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0034976 response to endoplasmic reticulum stress
GO:0042593 glucose homeostasis
GO:0043069 negative regulation of programmed cell death
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0045862 positive regulation of proteolysis
GO:0045927 positive regulation of growth
GO:0050821 protein stabilization
GO:0050877 neurological system process
GO:0051247 positive regulation of protein metabolic process
GO:0051928 positive regulation of calcium ion transport
GO:0055074 calcium ion homeostasis
GO:0070845 polyubiquitinated misfolded protein transport
GO:1902236 negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:2000675 negative regulation of type B pancreatic cell apoptotic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0030176 integral component of endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL G3N348
UniProt Splice Variant
Entrez Gene 100298456
UniGene Bt.96841
RefSeq XP_002688446
HUGO HGNC:12762
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02018366
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca