InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CARM1

Summary

InnateDB Protein

IDBP-695962.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CARM1

Protein Name

coactivator-associated arginine methyltransferase 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000015985

InnateDB Gene

IDBG-643387 (CARM1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.

Predicted by orthology
Total	50 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008276	protein methyltransferase activity
GO:0008469	histone-arginine N-methyltransferase activity
GO:0016274	protein-arginine N-methyltransferase activity
GO:0016740	transferase activity
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity
GO:0035642	histone methyltransferase activity (H3-R17 specific)
GO:0042054	histone methyltransferase activity
GO:0042803	protein homodimerization activity
GO:0044212	transcription regulatory region DNA binding
GO:0070577	lysine-acetylated histone binding

Biological Process

GO:0003420	regulation of growth plate cartilage chondrocyte proliferation
GO:0006355	regulation of transcription, DNA-templated
GO:0006479	protein methylation
GO:0008152	metabolic process
GO:0008284	positive regulation of cell proliferation
GO:0009405	pathogenesis
GO:0016571	histone methylation
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0030518	intracellular steroid hormone receptor signaling pathway
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0032091	negative regulation of protein binding
GO:0032259	methylation
GO:0033146	regulation of intracellular estrogen receptor signaling pathway
GO:0034969	histone arginine methylation
GO:0034970	histone H3-R2 methylation
GO:0034971	histone H3-R17 methylation
GO:0035246	peptidyl-arginine N-methylation
GO:0045600	positive regulation of fat cell differentiation
GO:0060350	endochondral bone morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR007848 Methyltransferase small domain
IPR010456 Ribosomal L11 methyltransferase, PrmA
IPR013216 Methyltransferase type 11
IPR020989 Histone-arginine methyltransferase CARM1, N-terminal
IPR025799 Protein arginine N-methyltransferase
IPR027555 tRNA (mo5U34)-methyltransferase-like
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF05175
PF06325
PF08241
PF11531
PF05185
PF08003

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-