Version 5.4
Bos taurus Protein: SLC9A3R1
Summary
InnateDB Protein IDBP-695968.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC9A3R1
Protein Name Na(+)/H(+) exchange regulatory cofactor NHE-RF1
Synonyms EBP50; NHERF-1;
Species Bos taurus
Ensembl Protein ENSBTAP00000034568
InnateDB Gene IDBG-643412 (SLC9A3R1)
Protein Structure
UniProt Annotation
Function Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Apical cell membrane {ECO:0000250}. Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cell projection, microvillus {ECO:0000250}. Note=Colocalizes with actin in microvilli-rich apical regions of the syncytiotrophoblast. Present in lipid rafts of T-cells. Translocates from the cytoplasm to the apical cell membrane in a PODXL-dependent manner. Colocalizes with CFTR at the midpiece of sperm tail (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.
Predicted by orthology
Total 58 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0017081 chloride channel regulator activity
GO:0019902 phosphatase binding
GO:0030165 PDZ domain binding
GO:0031698 beta-2 adrenergic receptor binding
GO:0043621 protein self-association
GO:0050780 dopamine receptor binding
GO:0070851 growth factor receptor binding
Biological Process
GO:0003096 renal sodium ion transport
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0008285 negative regulation of cell proliferation
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0010766 negative regulation of sodium ion transport
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0016055 Wnt signaling pathway
GO:0030033 microvillus assembly
GO:0030036 actin cytoskeleton organization
GO:0030336 negative regulation of cell migration
GO:0030643 cellular phosphate ion homeostasis
GO:0032416 negative regulation of sodium:hydrogen antiporter activity
GO:0032782 bile acid secretion
GO:0034613 cellular protein localization
GO:0034635 glutathione transport
GO:0044062 regulation of excretion
GO:0045859 regulation of protein kinase activity
GO:0051898 negative regulation of protein kinase B signaling
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway
GO:0070293 renal absorption
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0097291 renal phosphate ion absorption
GO:2000146 negative regulation of cell motility
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0030175 filopodium
GO:0031526 brush border membrane
GO:0031528 microvillus membrane
GO:0042995 cell projection
GO:0043231 intracellular membrane-bounded organelle
GO:0045177 apical part of cell
GO:0070062 extracellular vesicular exosome
GO:0071944 cell periphery
GO:0097225 sperm midpiece
Protein Structure and Domains
PDB ID
InterPro IPR001478 PDZ domain
IPR015098 EBP50, C-terminal
IPR017300 Na(+)/H(+) exchange regulatory cofactor NHE-RF
PFAM PF00595
PF13180
PF09007
PRINTS
PIRSF PIRSF037866
SMART SM00228
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3SZK8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 505242
UniGene Bt.44195
RefSeq NP_001071320
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102807
GenPept AAI02808

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca