InnateDB Protein
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IDBP-696016.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SDHAF2
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Protein Name
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Succinate dehydrogenase assembly factor 2, mitochondrial
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000020305
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InnateDB Gene
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IDBG-643460 (SDHAF2)
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Protein Structure
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Function |
Required for insertion of FAD cofactor into SDHA, the catalytic subunit of succinate dehydrogenase (SDH). SDH is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). In is unclear whether it participates in the chemistry of FAD attachment (enzymatic function) or acts as a chaperone that maintains SDHA in a conformation that is susceptible to autocatalytic FAD attachment. {ECO:0000255HAMAP- Rule:MF_03057}.
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Subcellular Localization |
Mitochondrion {ECO:0000255HAMAP- Rule:MF_03057}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
15 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005631
Flavinator of succinate dehydrogenase
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PFAM |
PF03937
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q3ZBC2
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
767983
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UniGene |
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RefSeq |
NP_001070513
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC103446
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GenPept |
AAI03447
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