Version 5.4
Bos taurus Protein: METTL21A
Summary
InnateDB Protein IDBP-696027.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol METTL21A
Protein Name Methyltransferase-like protein 21A
Synonyms FAM119A;
Species Bos taurus
Ensembl Protein ENSBTAP00000007203
InnateDB Gene IDBG-643473 (METTL21A)
Protein Structure
UniProt Annotation
Function Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys- 564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys- 561' in HSPA8 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0016279 protein-lysine N-methyltransferase activity
GO:0016740 transferase activity
GO:0030544 Hsp70 protein binding
GO:0051117 ATPase binding
Biological Process
GO:0006479 protein methylation
GO:0018022 peptidyl-lysine methylation
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR019410 Nicotinamide N-methyltransferase-like
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM PF10294
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A4FV42
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 615773
UniGene Bt.91877
RefSeq NP_001076987
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123706
GenPept AAI23707

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca