InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PIKFYVE

Summary

InnateDB Protein

IDBP-696094.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIKFYVE

Protein Name

phosphoinositide kinase, FYVE finger containing

Synonyms

fab1-like; PIP5K3;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000002824

InnateDB Gene

IDBG-643520 (PIKFYVE)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016307	phosphatidylinositol phosphate kinase activity
GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:0046872	metal ion binding

Biological Process

GO:0032288	myelin assembly
GO:0034504	protein localization to nucleus
GO:0035556	intracellular signal transduction
GO:0042147	retrograde transport, endosome to Golgi
GO:0044267	cellular protein metabolic process
GO:0046488	phosphatidylinositol metabolic process
GO:0046854	phosphatidylinositol phosphorylation

Cellular Component

GO:0005829	cytosol
GO:0005911	cell-cell junction
GO:0010008	endosome membrane
GO:0012506	vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0031901	early endosome membrane
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000306 FYVE zinc finger
IPR000591 DEP domain
IPR002423 Chaperonin Cpn60/TCP-1
IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core
IPR011011 Zinc finger, FYVE/PHD-type
IPR012336 Thioredoxin-like fold
IPR016034 Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup
IPR017455 Zinc finger, FYVE-related
IPR027409 GroEL-like apical domain

PFAM