Bos taurus Protein: UBXN1 | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||
InnateDB Protein | IDBP-696210.2 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | UBXN1 | ||||||||||||||
Protein Name | UBX domain-containing protein 1 | ||||||||||||||
Synonyms | SAKS1; | ||||||||||||||
Species | Bos taurus | ||||||||||||||
Ensembl Protein | ENSBTAP00000013845 | ||||||||||||||
InnateDB Gene | IDBG-643641 (UBXN1) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | Ubiquitin-binding protein that interacts with the BRCA1- BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol (By similarity). {ECO:0000250}. | ||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000250}. | ||||||||||||||
Disease Associations | |||||||||||||||
Tissue Specificity | |||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 82 interaction(s) predicted by orthology.
|
||||||||||||||
Gene Ontology | |||||||||||||||
Molecular Function |
|
||||||||||||||
Biological Process |
|
||||||||||||||
Cellular Component |
|
||||||||||||||
Protein Structure and Domains | |||||||||||||||
PDB ID | |||||||||||||||
InterPro |
IPR000449
Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal IPR001012 UBX domain IPR009060 UBA-like IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote IPR029071 Ubiquitin-related domain |
||||||||||||||
PFAM |
PF00627
PF00789 |
||||||||||||||
PRINTS | |||||||||||||||
PIRSF | |||||||||||||||
SMART |
SM00166
SM00165 |
||||||||||||||
TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | Q32KW2 | ||||||||||||||
PhosphoSite | PhosphoSite- | ||||||||||||||
TrEMBL | |||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 506676 | ||||||||||||||
UniGene | Bt.8001 | ||||||||||||||
RefSeq | NP_001032677 | ||||||||||||||
HUGO | |||||||||||||||
OMIM | |||||||||||||||
CCDS | |||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | BC109898 | ||||||||||||||
GenPept | AAI09899 | ||||||||||||||