InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BSCL2

Summary

InnateDB Protein

IDBP-696225.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BSCL2

Protein Name

Seipin

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000003254

InnateDB Gene

IDBG-643647 (BSCL2)

Protein Structure

UniProt Annotation

Function

Is a regulator of lipid catabolism essential for adipocyte differentiation. Necessary for correct lipid storage and lipid droplets maintenance; may play a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May also be involved in the central regulation of energy homeostasis (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0006629	lipid metabolic process
GO:0008150	biological_process
GO:0016042	lipid catabolic process
GO:0019915	lipid storage
GO:0034389	lipid particle organization
GO:0045444	fat cell differentiation
GO:0050995	negative regulation of lipid catabolic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane