Version 5.4
Bos taurus Protein: GNG3
Summary
InnateDB Protein IDBP-696226.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNG3
Protein Name Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000003257
InnateDB Gene IDBG-643658 (GNG3)
Protein Structure
UniProt Annotation
Function Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.
Subcellular Localization Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Disease Associations
Tissue Specificity Abundantly expressed in brain. Low levels in testis. {ECO:0000269PubMed:2122451}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
Biological Process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
Cellular Component
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001770 G-protein, gamma subunit
IPR015898 G-protein gamma-like domain
PFAM PF00631
PRINTS PR00321
PIRSF
SMART SM00224
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P63214
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281204
UniGene Bt.5464
RefSeq NP_776498
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC109874 M58349
GenPept AAA30539 AAI09875

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca