InnateDB Protein
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IDBP-69626.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CASP1
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Protein Name
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caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
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Synonyms
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ICE; IL1BC; P45;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000344132
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InnateDB Gene
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IDBG-69618 (CASP1)
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Protein Structure
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Function |
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. {ECO:0000269PubMed:15498465, ECO:0000269PubMed:7876192}.
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Subcellular Localization |
Cytoplasm.
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Disease Associations |
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Tissue Specificity |
Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain. {ECO:0000269PubMed:15498465}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
82
[view]
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Protein-Protein |
79
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004175
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endopeptidase activity
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GO:0004197
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cysteine-type endopeptidase activity
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GO:0005515
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protein binding
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GO:0008234
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cysteine-type peptidase activity
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GO:0008656
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cysteine-type endopeptidase activator activity involved in apoptotic process
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Biological Process |
GO:0006508
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proteolysis
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GO:0006915
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apoptotic process
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GO:0006919
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activation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0007165
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signal transduction
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GO:0035872
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nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
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GO:0043123
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positive regulation of I-kappaB kinase/NF-kappaB signaling
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GO:0045087
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innate immune response (InnateDB)
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GO:0050727
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regulation of inflammatory response
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GO:0071260
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cellular response to mechanical stimulus
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GO:0071310
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cellular response to organic substance
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GO:0097194
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execution phase of apoptosis
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Cellular Component |
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PDB ID |
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InterPro |
IPR002138
Peptidase C14, caspase non-catalytic subunit p10
IPR015917
Peptidase C14A, caspase precursor p45, core
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PFAM |
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PRINTS |
PR00376
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PIRSF |
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SMART |
SM00115
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TIGRFAMs |
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Modification |
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SwissProt |
P29466
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PhosphoSite |
PhosphoSite-P29466
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
834
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UniGene |
Hs.2490
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RefSeq |
NP_150637
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HUGO |
HGNC:1499
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OMIM |
147678
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CCDS |
CCDS8332
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HPRD |
00977
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IMGT |
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EMBL |
AK223503
AP001153
AY660536
BC041689
BC062327
M87507
U13697
U13698
U13699
U13700
X65019
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GenPept |
AAA66942
AAC50107
AAC50108
AAC50109
AAC50110
AAH41689
AAH62327
AAT72297
BAD97223
CAA46153
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