Version 5.4
Bos taurus Protein: PNKD
Summary
InnateDB Protein IDBP-696387.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PNKD
Protein Name Probable hydrolase PNKD
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000005141
InnateDB Gene IDBG-643795 (PNKD)
Protein Structure
UniProt Annotation
Function Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway. {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004416 hydroxyacylglutathione hydrolase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006750 glutathione biosynthetic process
GO:0032225 regulation of synaptic transmission, dopaminergic
GO:0042053 regulation of dopamine metabolic process
GO:0050884 neuromuscular process controlling posture
Cellular Component
GO:0005739 mitochondrion
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001279 Beta-lactamase-like
IPR017782 Hydroxyacylglutathione hydrolase
PFAM PF00753
PRINTS
PIRSF PIRSF005457
SMART SM00849
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A7YY46
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 786287
UniGene Bt.11304
RefSeq NP_001107642
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC151298
GenPept AAI51299

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca