InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CERS4

Summary

InnateDB Protein

IDBP-696395.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CERS4

Protein Name

Ceramide synthase 4

Synonyms

LASS4;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000004459

InnateDB Gene

IDBG-643805 (CERS4)

Protein Structure

UniProt Annotation

Function

May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus membrane {ECO:0000255PROSITE- ProRule:PRU00108}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding
GO:0050291	sphingosine N-acyltransferase activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006629	lipid metabolic process
GO:0030148	sphingolipid biosynthetic process
GO:0046513	ceramide biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001356 Homeobox domain
IPR006634 TRAM/LAG1/CLN8 homology domain
IPR009057 Homeodomain-like
IPR016439 Longevity assurance, LAG1/LAC1

PFAM

PF00046
PF03798

PRINTS

PIRSF

PIRSF005225

SMART

SM00389
SM00724

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5E9R6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

505233

UniGene

Bt.2268

RefSeq

NP_001015520

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC120450 BT020828 BT020854 BT026335

GenPept

AAI20451 AAX08845 AAX08871 ABG81491