InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MACROD1

Summary

InnateDB Protein

IDBP-696458.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MACROD1

Protein Name

MACRO domain-containing protein 1

Synonyms

LRP16;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000022832

InnateDB Gene

IDBG-643865 (MACROD1)

Protein Structure

UniProt Annotation

Function

Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016798	hydrolase activity, acting on glycosyl bonds
GO:0019213	deacetylase activity

Biological Process

GO:0006974	cellular response to DNA damage stimulus
GO:0042278	purine nucleoside metabolic process
GO:0051725	protein de-ADP-ribosylation

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR002589 Macro domain

PFAM

PF01661

PRINTS

PIRSF

SMART

SM00506

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2KHU5

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

613568

UniGene

RefSeq

NP_001039974

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC112879

GenPept

AAI12880