Version 5.4
Bos taurus Protein: UVSSA
Summary
InnateDB Protein IDBP-696484.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UVSSA
Protein Name KIAA1530
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000016697
InnateDB Gene IDBG-643889 (UVSSA)
Protein Structure
UniProt Annotation
Function Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage (By similarity). {ECO:0000250}.
Subcellular Localization Chromosome {ECO:0000250}. Note=Accumulates at UV DNA damage sites. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000993 RNA polymerase II core binding
GO:0005515 protein binding
Biological Process
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006974 cellular response to DNA damage stimulus
GO:0009411 response to UV
GO:0016567 protein ubiquitination
Cellular Component
GO:0005694 chromosome
Protein Structure and Domains
PDB ID
InterPro IPR008942 ENTH/VHS
IPR018610 Protein of unknown function DUF2043
PFAM PF09740
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt F1MX48
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 510550
UniGene Bt.61491
RefSeq XP_002688500
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02018546
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca