InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.19562

Summary

InnateDB Protein

IDBP-696536.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.19562

Protein Name

complement C3

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000022979

InnateDB Gene

IDBG-643930 (BT.19562)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004866	endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0031715	C5L2 anaphylatoxin chemotactic receptor binding

Biological Process

GO:0001798	positive regulation of type IIa hypersensitivity
GO:0001934	positive regulation of protein phosphorylation
GO:0001970	positive regulation of activation of membrane attack complex
GO:0006954	inflammatory response
GO:0006956	complement activation
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0010828	positive regulation of glucose transport
GO:0010866	regulation of triglyceride biosynthetic process
GO:0010884	positive regulation of lipid storage
GO:0010951	negative regulation of endopeptidase activity
GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway
GO:0045766	positive regulation of angiogenesis
GO:0050766	positive regulation of phagocytosis
GO:2000427	positive regulation of apoptotic cell clearance

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

InterPro

IPR000020 Anaphylatoxin/fibulin
IPR001134 Netrin domain
IPR001599 Alpha-2-macroglobulin
IPR001840 Anaphylatoxin, complement system domain
IPR002890 Alpha-2-macroglobulin, N-terminal
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
IPR009048 Alpha-macroglobulin, receptor-binding
IPR011625 Alpha-2-macroglobulin, N-terminal 2
IPR011626 Alpha-macroglobulin complement component
IPR018081 Anaphylatoxin, complement system
IPR018933 Netrin module, non-TIMP type
IPR019565 Alpha-2-macroglobulin, thiol-ester bond-forming

PFAM