Version 5.4
Bos taurus Protein: ATG9A
Summary
InnateDB Protein IDBP-696560.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATG9A
Protein Name Autophagy-related protein 9A
Synonyms ATG9;
Species Bos taurus
Ensembl Protein ENSBTAP00000027461
InnateDB Gene IDBG-643961 (ATG9A)
Protein Structure
UniProt Annotation
Function Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasmic vesicle, autophagosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Late endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015002 heme-copper terminal oxidase activity
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0000422 mitochondrion degradation
GO:0006810 transport
GO:0006914 autophagy
GO:0015031 protein transport
GO:0034497 protein localization to pre-autophagosomal structure
GO:0034727 piecemeal microautophagy of nucleus
GO:0044805 late nucleophagy
Cellular Component
GO:0000407 pre-autophagosomal structure
GO:0000421 autophagic vacuole membrane
GO:0005768 endosome
GO:0005776 autophagic vacuole
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031410 cytoplasmic vesicle
GO:0031902 late endosome membrane
Protein Structure and Domains
PDB ID
InterPro IPR000298 Cytochrome c oxidase subunit III domain
IPR007241 Autophagy-related protein 9
PFAM PF00510
PF04109
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3T904
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 540482
UniGene Bt.7411
RefSeq NP_001029878
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AM085499 BC140511
GenPept AAI40512 CAJ30197

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca