Version 5.4
Bos taurus Protein: ALKBH7
Summary
InnateDB Protein IDBP-696573.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALKBH7
Protein Name Probable alpha-ketoglutarate-dependent dioxygenase ABH7
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000035795
InnateDB Gene IDBG-643973 (ALKBH7)
Protein Structure
UniProt Annotation
Function Probable dioxygenase required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion matrix {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006974 cellular response to DNA damage stimulus
GO:0010883 regulation of lipid storage
GO:0012501 programmed cell death
GO:0055114 oxidation-reduction process
GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2M2S8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 535305
UniGene Bt.6558
RefSeq NP_001039867
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC111665
GenPept AAI11666

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca