Version 5.4
Bos taurus Protein: CLPP
Summary
InnateDB Protein IDBP-696575.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLPP
Protein Name Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000019577
InnateDB Gene IDBG-643974 (CLPP)
Protein Structure
UniProt Annotation
Function Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion matrix {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006508 proteolysis
GO:0051603 proteolysis involved in cellular protein catabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0009368 endopeptidase Clp complex
Protein Structure and Domains
PDB ID
InterPro IPR001907 ATP-dependent Clp protease proteolytic subunit
IPR023562 Clp protease proteolytic subunit /Translocation-enhancing protein TepA
IPR029045 ClpP/crotonase-like domain
PFAM PF00574
PRINTS PR00127
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2KHU4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 535981
UniGene Bt.54443
RefSeq NP_001039879
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC112880
GenPept AAI12881

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca