InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLDN16

Summary

InnateDB Protein

IDBP-69658.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLDN16

Protein Name

claudin 16

Synonyms

HOMG3; PCLN1;

Species

Homo sapiens

Ensembl Protein

ENSP00000264734

InnateDB Gene

IDBG-69656 (CLDN16)

Protein Structure

UniProt Annotation

Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors.

Subcellular Localization

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Disease Associations

Hypomagnesemia 3 (HOMG3) [MIM:248250]: A progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis. Recurrent urinary tract infections and kidney stones are often observed. In spite of hypercalciuria, patients do not show hypocalcemia. {ECO:0000269PubMed:10390358, ECO:0000269PubMed:10878661, ECO:0000269PubMed:11518780}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Kidney-specific, including the thick ascending limb of Henle (TAL).

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0015095	magnesium ion transmembrane transporter activity
GO:0042802	identical protein binding