InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SNRPD1

Summary

InnateDB Protein

IDBP-696659.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNRPD1

Protein Name

Small nuclear ribonucleoprotein Sm D1

Synonyms

SNRPD1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000010912

InnateDB Gene

IDBG-644053 (SNRPD1)

Protein Structure

UniProt Annotation

Function

Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0000387	spliceosomal snRNP assembly
GO:0006397	mRNA processing
GO:0008380	RNA splicing

Cellular Component

GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005685	U1 snRNP
GO:0005687	U4 snRNP
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030529	ribonucleoprotein complex
GO:0034709	methylosome
GO:0034715	pICln-Sm protein complex
GO:0034719	SMN-Sm protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR001163 Ribonucleoprotein LSM domain
IPR006649 Ribonucleoprotein LSM domain, eukaryotic/archaea-type
IPR010920 Like-Sm (LSM) domain

PFAM

PF01423

PRINTS

PIRSF

SMART

SM00651

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3ZC10

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

786829

UniGene

Bt.49433

RefSeq

NP_001030237

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102987

GenPept

AAI02988