Version 5.4
Bos taurus Protein: AZI2
Summary
InnateDB Protein IDBP-696666.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AZI2
Protein Name 5-azacytidine-induced protein 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000005379
InnateDB Gene IDBG-644062 (AZI2)
Protein Structure
UniProt Annotation
Function Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine- protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0001816 cytokine production
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0032607 interferon-alpha production
GO:0032609 interferon-gamma production
GO:0032635 interleukin-6 production
GO:0032640 tumor necrosis factor production
GO:0042110 T cell activation
GO:0044565 dendritic cell proliferation
GO:0097028 dendritic cell differentiation
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3SYW5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 767932
UniGene Bt.59796
RefSeq NP_001070473
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103353
GenPept AAI03354

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca