Version 5.4
Bos taurus Protein: MYC
Summary
InnateDB Protein IDBP-696761.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYC
Protein Name Myc proto-oncogene protein
Synonyms CMYC;
Species Bos taurus
Ensembl Protein ENSBTAP00000011066
InnateDB Gene IDBG-644147 (MYC)
Protein Structure
UniProt Annotation
Function Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'- CAC[GA]TG-3'. Activates the transcription of growth-related genes (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 662 interaction(s) predicted by orthology.
Predicted by orthology
Total 662 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0032403 protein complex binding
GO:0046983 protein dimerization activity
GO:0070491 repressing transcription factor binding
GO:0070888 E-box binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000165 MAPK cascade
GO:0001836 release of cytochrome c from mitochondria
GO:0006309 apoptotic DNA fragmentation
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006879 cellular iron ion homeostasis
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007050 cell cycle arrest
GO:0008284 positive regulation of cell proliferation
GO:0009314 response to radiation
GO:0010332 response to gamma radiation
GO:0010468 regulation of gene expression
GO:0032204 regulation of telomere maintenance
GO:0032873 negative regulation of stress-activated MAPK cascade
GO:0034644 cellular response to UV
GO:0035690 cellular response to drug
GO:0042493 response to drug
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045656 negative regulation of monocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048146 positive regulation of fibroblast proliferation
GO:0048147 negative regulation of fibroblast proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051276 chromosome organization
GO:0051782 negative regulation of cell division
GO:0060070 canonical Wnt signaling pathway
GO:0097193 intrinsic apoptotic signaling pathway
GO:2000573 positive regulation of DNA biosynthetic process
GO:2001022 positive regulation of response to DNA damage stimulus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005819 spindle
GO:0016604 nuclear body
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR002418 Transcription regulator Myc
IPR003327 Leucine zipper, Myc
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR012682 Transcription regulator Myc, N-terminal
PFAM PF02344
PF00010
PF01056
PRINTS PR00044
PIRSF PIRSF001705
SMART SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2HJ27
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 511077
UniGene Bt.21164
RefSeq NP_001039539
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC113343
GenPept AAI13344

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca